Vendor Reviews
GLP-1 drugs are peptide medications that copy a hormone your gut already makes to manage appetite and blood sugar. ⚠ NEEDS MEDICAL REVIEW Two of them are FDA-approved for weight loss in the United States: semaglutide and tirzepatide. A third one you’ve probably heard about — retatrutide — is not approved and is still working its way through trials.
That’s the whole map. If the word “peptide” is doing a lot of unexplained work here, start with what a peptide actually is, then come back — the rest of this page assumes you know these are short chains of amino acids, not a supplement category.
Regulatory status: Semaglutide (Wegovy) and tirzepatide (Zepbound) are FDA-approved for chronic weight management; retatrutide is investigational and not FDA-approved, as of September 2026. This changes — we check it quarterly.
